Hepato-protective role of Diphenyl diselenide in Streptozotocin-Induced Diabetic Rats

Abstract

Diabetic hepatopathy prevalence as a result of prolonged hyperglycemia is increasing with the expanding size of the diabetes population around the world. In this present study, the hepato-protective activity of diphenyl diselenide (DPDSe) in a persistent diabetic state was studied. Diabetes mellitus were induced with streptozotocin (STZ) (60 mg/kg) intraperitoneally and after 60 days without treatment, the rats were administered diphenyl dislenide (DPDSe) (10 mg/kg) orally for 35 days. Animals were euthanized liver and serum were used for experimental determinations such as glycemic level, non-enzymic and enzymic redox statuses, hepatic biomarkers, hematological and lipid profile.  The results showed that the fasting glucose levels and thiobarbituric reactive substances were reduced at a significant level of p < 0.05. Furthermore, a concomitant rise in the percentage of DPPH free radicals scavenged, ferric reducing antioxidants property, protein and non-protein thiols were observed in hepatic tissue. The activities of delta–aminolevulinate dehydratase and antioxidant enzymes were improved at a significant level of p < 0.05. Additionally, there was significant reduction (p < 0.05) in the activity of the purinergic enzymes, hepatic biomarkers while there was an increase in the albumin level. Furthermore, the hematological and lipid profile of were refurbished. This study showed that DPDSe was able to reverse the biochemical alterations related with hepatic tissue in STZ-induced diabetic rats.